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Statistics for Molecular Biomedicine


Semesterangivelse: Efterårs kursus Kurset udbydes i blok 2 Kurset udbydes i skemagruppe A Kurset giver 7,5 ETCS point

 


Udgave: Efterår 2012 NAT
ECTS points: 7,5
Point: 7,5
Blokstruktur: 2. blok
Skemagruppe: A
Institutter: Department of Biology
Uddannelsesdel: Kandidat niveau
Kontaktpersoner: Anders Krogh, krogh@binf.ku.dk , tlf. +45 3532 1329.
Skema- oplysninger:  Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT
Undervisnings- form: Lectures and interactive exercises in R
Indhold:
  • Descriptive statistics
  • Distributions
  • Study design
  • Hypothesis testing/ interval estimation
  • Non-parametric methods
  • Analysis of variance
  • Linear regression
  • Multiple testing
  • The statistical program R
Kompetence- beskrivelse: At the end of the course the students should be able to:
  • Set up statistical models for data of biological and/or medical relevance - taking as a starting point models based on the normal distribution.
  • Handle the symbolic language of statistics and the corresponding formalism for models based on the normal distribution and be able to carry out necessary calculations. This includes:
    - mastering the formulation of linear regression
    - mastering analysis of variance
  • Perform significance testing, p-value calculation and interpretation for simple experimental data, including compute-intensive techniques such as permutation testing.
  • Discuss the problem and possible interpretations of multiple hypothesis tests for biological data and have knowledge of the common corrections.
  • Report the results of model set up, data analysis, interpretation and assessment in a coherent and well documented report.
  • Apply R for the practical statistical analysis of biological data such as gene expression data.
Målbeskrivelse:
  • Set up statistical models for data of biological and/or medical relevance - taking as a starting point models based on the normal distribution.
  • Handle the symbolic language of statistics and the corresponding formalism for models based on the normal distribution and be able to carry out necessary calculations. This includes:
    - mastering the formulation of linear regression
    - mastering analysis of variance
  • Perform significance testing, p-value calculation and interpretation for simple experimental data, including compute-intensive techniques such as permutation testing.
  • Discuss the problem and possible interpretations of multiple hypothesis tests for biological data and have knowledge of the common corrections.
  • Report the results of model set up, data analysis, interpretation and assessment in a coherent and well documented report.
  • Apply R for the practical statistical analysis of biological data such as gene expression data.
Lærebøger: Biostatistics, Second Edition: A Guide to Design, Analysis and Discovery by Ronald N. Forthofer, Eun Sul Lee, Mike Hernandez, Academic Press
Tilmelding: Registration via KUnet 15 May - 1 June.
Eksamensform: Continuous Assessment: Three take-home assignments during course. Internal censors. Grade given by 7-pointscale. Re-exam will consist of an additional 3-day assignment.
Eksamen: Løbende evaluering. Reeksamen: 3 dages opgave udleveres den 15. april og afleveres den 17. april 2012.
Kursus hjemmeside:
Kursus hjemmeside: Course wiki
Bemærkninger: The course will involve interactive R sessions and so students will need to bring a laptop computer to lectures.
Pensum: Recommended Reading: Introductory Statistics with R by Peter Dalgaard (1st or 2nd ed) (an electronic version is available at the library web site).
Undervisnings- sprog: Kun engelsk
Sidst redigeret: 27/4-2012



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