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Theoretical Molecular Genetics


Semesterangivelse: Efterårs kursus Kurset udbydes i blok 1 Kurset udbydes i skemagruppe B Kurset giver 7,5 ETCS point

 


Udgave: Efterår 2012 NAT
Point: 7,5
Blokstruktur: 1. blok
Skemagruppe: B
Fagområde: andet
Institutter: Biologisk Institut
Uddannelsesdel: Bachelor niveau
Kontaktpersoner: Steen Holmberg, gensteen@bio.ku.dk, 35 32 21 19
Skema- oplysninger:
Lectures and problem solving:
Weeks 36-41, Monday and Friday from 9 to 12, week 43 Monday from 10 to 12
Introduction to articles:
Weeks 36-38, Tuesday from 13 to 14 or from 14 to 15
Presentation of articles:
Weeks 39-41, Tuesday from 13 to 15
Skema- oplysninger:  Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT
Undervisnings- periode: See home page for venue of first meeting.
Formål: Large scale genome projects are presently yielding the complete genome DNA sequences of animals, plants and microorganisms across the globe. Assigning functions to the many new genes of these genomes is a major goal in biology today. This information will produce new tools for plant and animal breeders as well as for the medical and biopharmaceutical industry. The overall goal of the course is for students to understand the genetics that underlie modern biology and medicine including the genetics of human diseases, genetic screens and diagnostics. The participants in the course will acquire a solid background in the principles of genetics and get an introduction to the latest developments while integrating genetics and molecular biology.
Participants will develop quantitative, analytical skills with which to interpret experimental data and solve problems in classical and molecular genetics plus epigenetics and genomics. This knowledge will enable the student to subsequently apply the genetic approach to gain an understanding of almost any biological system. Another goal is to train the students in both oral and written presentation of scientific data. This includes practice in (i) how to critically read original literature during group discussions and (ii) oral presentation of seminars based on articles.
Indhold: Principles of genetics and genomics at the molecular level will be explored to give students a solid grasp of the genetic approaches used for solving biological and medical problems. The analysis of eukaryotic genomes encompasses mapping of disease causing mutations and DNA markers (RFLP, RAPD, STS etc) by recombination analyses, and the use of genetic model systems to understand basic biological mechanisms. Topics also include gene mutants in forward and reverse genetics; recombination, gene conversion and repair; gene expression, chromatin and regulation; gene functions and networks plus an introduction to epigenetics and gene databases.
Målbeskrivelse:
To obtain the top grade, 12
  • Can solve problems in recombination, mutation, function and regulation of genes and DNA sequences, gene isolation plus gene and genome structure as presented in the recommended textbook and supplemented by the lectures, problem solving, articles and laboratory exercises.
  • Can integrate the material from the various topics taught in the course.
  • Present an article and/or act as a questioner/opponent for an article in English using PowerPoint, demonstrating an understanding of the experimental methods and results.
  • Actively participate in English as a member of the audience in the article training sessions, the article presentations as well as in the problem solving sessions.
  • Lærebøger: Griffiths, A., Wesslar, S., Carroll, S. and Doebley, J.: An Introduction to Genetic Analysis, 10th ed. W.H. Freeman, 2010.
    Tilmelding: Enrolment through KUnet during the period 15 May - 1 June.
    Faglige forudsætninger: Open to students studying biochemistry, biology, nanotechnology and molecular biomedicine who have passed all first year courses and half of the second year courses (corresponding to a total of 90 ECTS-points) of their curriculum. Other students must have successfully completed biochemistry and molecular biology courses at the undergraduate level.
    Eksamensform: A 4 hour written exam at which text book and course manuals are permitted. Grading according to the 7-step scale with participation of external censor.
    Reexam will be held as the ordinary exam.
    Eksamen: Skriftlig prøve den 2. november 2012. Reeksamen: Mundtlig prøve den 28. januar 2013.
    Kursus hjemmeside:
    Kursus hjemmeside: Log on KUnet and then choose Absalon in the right menu.
    Bemærkninger: Minimum of 6 students.
    Teaching language will be English.
    Undervisnings- sprog: Kun engelsk
    Sidst redigeret: 21/1-2013



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