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| Udgave: |
Forår 2013 NAT |
| ECTS points: |
5 |
| Point: |
5 |
| Blokstruktur: |
4. blok |
| Varighed: |
3 full weeks |
| Institutter: |
Department of Biology |
| Uddannelsesdel: |
Kandidat niveau |
| Kontaktpersoner: |
Morten Johnsen, Department of Biology, mortenj@bio.ku.dk |
| Andre undervisere: |
Tuk Wah Soong, Christoph Winkler, and Reshma Taneja, all from National University of Singapore. |
| Undervisnings- periode: |
Summer |
| Undervisnings- form: |
Lectures, presentations/discussion, CA, group work. The course will mainly be based on key scientific papers and review articles. |
| Indhold: |
This module is designed to introduce students to neuromuscular development and disease. Three weeks teaching period with 4 hours of lectures and group discussions each day. In addition, students will be given individual and group assignments to prepare presentations based on the original litterature in the field.
Major topics to be covered include:
1. Muscle Biology
1.1. Development of skeletal muscle
1.2. Differentiation of muscle stem cells
1.3. Muscle stem cells in regeneration
1.4. Muscle degenerative diseases and stem cell based therapies
2. Development of the nervous system
2.1. Neural induction and patterning
2.2. Differentiation in central and peripheral nervous system
2.3. Neuroregeneration and neural stem cells
2.4. Animal models for human neurodegenerative diseases
3. Neurobiology
3.1. Ionic basis of neuronal signalling
3.2. Molecular biology of ion channels & ion channelopathies
3.3. Development of neuromuscular junction
3.4. Auditory system
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| Målbeskrivelse: |
Knowledge:
After completing the module, students will
Know and understand the processes involved in the development of skeletal muscle
Know and understand the processes involved in differentiation of muscle stem cells
Know and understand the role of muscle stem cells in regeneration
Know and understand the molecular basis for several muscle disorders and therapies
Know and understand the processes involved in the development of the neuromuscular junction
Know and understand the ionic basis of neuronal signalling
Know and understand the molecular mechanisms underlying ion channel function
Know and understand the molecular mechanisms behind selected ion channelopathies
Know and understand neural induction and patterning
Know and understand differentiation in the central and peripheral nervous systems
Know and understand the role of neural stem cells, also in neuroregeneration
Know and understand the molecular mechanisms underlying audition
Skills:
After completing the module, students will be able to
Understand and explain molecular mechanisms underlying skeletal muscle pathologies
Understand and explain molecular mechanisms underlying neurodegenerative disorders, ion channelopathies and regenerative processes.
Understand and critically evaluate the use of several methods for investigation of complex molecular interactions in muscle and neural function, development, differentiation and regeneration
Understand and critically evaluate the use of select animal models for specific muscular and neural pathologies, including muscular dystrophy, Spinal Muscular Atrophy, ALS and ion channelopathies.
Competencies:
At the end of the module, students will be able to:
Critically evaluate experimental results in the field of neuromuscular development and disease
Read, understand and critically evaluate recent original litterature in the field
Demonstrate the ability to review, analyse and test hypothesis of recent literature on the above topics.
Demonstrate a thorough understanding of molecular mechanisms in development and disease of skeletal muscle and in the central and peripheral nervous systems
Analyze, evaluate and condense experimental data and scientific models derived from these data
Demonstrate ability to present specific scientific problems and experiments designed to clarify these problems to their peers
Work in a small international group to analyze a given subset of the original litterature in order to identify and describe a scientific problem that has not been solved yet, and in the same group use this to formulate and present a limited proposal to address this problem in a stringent scientific manner, using an acknowledged set of methods
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| Lærebøger: |
Students will be given a list of selected materials, compiled by the lecturers, to read before the start of the programme as part of the preparation for the summer school. |
| Faglige forudsætninger: |
Open for University of Copenhagen students of Molecular Biomedicine, Biochemistry and Biology-Biotechnology. Priority will be given to students of Molecular Biomedicine. |
| Eksamensform: |
1 test. Continuous assessment. Tutorials/seminars; essays; group presentation. Passed/not passed with internal censorship. |
| Kursus hjemmeside: |
 |
| Bemærkninger: |
Course capacity: 30 (15 Life Sciences students from National University of Singapore (NUS) and 15 University of Copenhagen students) |
| Undervisnings- sprog: |
Engelsk
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| Sidst redigeret: |
15/5-2013 |