|
| Udgave: |
Forår 2013 NAT |
| ECTS points: |
7,5 for bachelors and masters and 10 for PhD |
| Point: |
7,5 |
| Blokstruktur: |
4. blok |
| Skemagruppe: |
B |
| Varighed: |
9 weeks |
| Omfang: |
4 hours of lecture per week. 2 hour of discussion of assignments per week for all. |
| Institutter: |
Department of Chemistry |
| Uddannelsesdel: |
Bachelor niveau, Kandidat niveau, Ph.D.-niveau |
| Kontaktpersoner: |
Dimitrios Stamou, 3532 0479, stamou@nano.ku.dk & Nikos Hatzakis, 3532 0499, hatzakis@nano.ku.dk |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Forår 2013 NAT |
| Undervisnings- form: |
Lectures |
| Formål: |
The aim of this class is to provide essential understanding of the lipid membrane-related nanoscale processes that control key elements of cellular life. |
| Indhold: |
Biological membranes are the nanoscale boundaries that separate the cytoplasm of the cell from the extracellular environment and define intracellular compartments and organelles. While initially recognized mostly as static, it is now established that membranes change shape and properties in striking ways thus controlling multiple fundamental processes of life such as cell signaling and sensory pathways. Their overall shape and characteristics is tightly regulated by a continuous interplay between the lipid constituents and membrane-associated proteins. On the other hand multiple’s protein function as well as trafficking and sorting are regulated by membrane characteristics and shape. As a result a multitude of essential cellular functions including endocytosis and signalling are controlled by the complex interplay between membrane properties and membrane associated proteins properties on the nanoscale.
The aim of this class is to provide essential understanding of the membrane-related nanoscale processes that control key elements of cellular life. Initially we will discuss the effect of membrane characteristics such as composition shape and nanodomain formation, on the dynamics and function of enzymes associated or activated by membranes. Some emphasis will be put on experiments of single molecule activity. We will continue with the mechanisms of membrane-mediated protein trafficking and sorting in cellular compartments and its relation to signaling pathways. Subsequently we will focus on nanoscale lipid assemblies (lipid vesicles) and will discuss the proteins and the mechanisms involved in membrane remodeling during cellular functions such as endocytosis, SNARE mediated fusion and vesicle trafficking. By the end of the class students will be well acquainted with a mechanistic knowledge of multiple membrane-related cellular functions and the latest nanoscale techniques used to characterize them.
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| Kompetence- beskrivelse: |
By the end of the exam, students:
1. Will obtain fundamental understanding of the properties of real (in vivo) and artificial (made in the lab) membranes
2. Will understand the interplay between the function of membrane related proteins and membrane properties
3. Obtain mechanistic understanding of cellular functions related to eg endocytosis, protein trafficking and signaling
4. Can describe the principles and advantages of the latest nanoscale techniques to characterize membranes
|
| Lærebøger: |
“Protein Lipid Interactions”,Wiley-VCH 2005, Ed. by Lukas Tamm |
| Tilmelding: |
Via www.kunet.dk i perioden 1. december - 10. december.
PhD students must apply as credit students. See more information about applying here. |
| Faglige forudsætninger: |
The Biology, Chemistry and Physics mandatory courses of first and second year of the Nano-Science education, or equivalent. |
| Eksamensform: |
The student must participate in lectures and solve exercises during the course. Assignments will be made each week and be due in the following week. 4 assignments out of the 6 must be completed by the due date and approved to qualify to take the exam. Assignments correspond to 30% of the final grade.
The exam will be a 4-hour written final exam, and will be graded using the 7-step scale with an internal censor.
Reexam:
If more than 10 students are signed up: Same as ordinary exam.
If 10 or fewer students are signed up: 30 minute oral exam without preparation.
To participate in the reexam it is required that at least 4 out of 6 written homework assignments from the course have been approved. Missing homework assignments must be handed in before the reexam.
|
| Eksamen: |
Skriftlig prøve d. 21. juni 2013.
Reeksamen: Skriftlig prøve d. 23. august 2013. Såfremt der er 10 eller færre tilmeldte til reeksamen, ændres eksamensformen til mundtlig. |
| Kursus hjemmeside: |
 |
| Pensum: |
Selected chapters from the textbook " Protein Lipid Interactions”,Wiley-VCH 2005, Ed. by Lukas Tamm, selected papers, and lecture notes |
| Undervisnings- sprog: |
Kun engelsk
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| Sidst redigeret: |
15/11-2012 |