|
| Udgave: |
Forår 2013 NAT |
| ECTS points: |
7,5 |
| Point: |
7,5 |
| Point: |
7,5 |
| Blokstruktur: |
4. blok |
| Skemagruppe: |
C |
| Fagområde: |
andet |
| Institutter: |
Department of Biology and Niels Bohr Institute |
| Uddannelsesdel: |
Bachelor niveau, Kandidat niveau |
| Kontaktpersoner: |
Sine Lo Svenningsen, Department of Biology, phone 3532 2033, e-mail: sls@bio.ku.dk and Namiko Mitarai, Niels Bohr Institute, phone 3532 5402, e-mail: mitarai@nbi.dk |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Forår 2013 NAT |
| Undervisnings- form: |
Each week, we read a scientific article that has made a significant contribution to basic biology through the use of quantitative reasoning and theory. An introduction to each paper is provided in the form of a lecture on the biological and mathematical concepts used. The students then read the article at home, and we discuss it in the classroom. In addition, a weekly exercise session provides an opportunity for the students to use the tools they learned to solve simple problems in a group setting. At the conclusion of the course, a group of students with different backgrounds help each other understand an assigned interdisciplinary article, and presents it to the class.
|
| Formål: |
The goal of the course is to introduce the basic knowledge and skills of biology, physics, and mathematics required for a modern, integrated understanding of dynamical biological systems. As the field of molecular biology is advancing from the description of isolated molecular mechanisms to a quantitative understanding also of their interactions and regulations at the systems-level, the need for mathematical literacy in biology has never been greater. This course is intended for students of diverse educational backgrounds within the natural sciences, who wish to gain competency in applying quantitative theory and logic to address questions in molecular biology. The course is co-taught by a biologist and a physicist, and aims to facilitate interdisciplinaty communication between students from different fields. |
| Indhold: |
Topics include the physics and biology of:
Gene regulatory mechanisms
Signal transduction
Mutational analysis
Bi-stability and noise in genetic networks
Modeling of biological networks.
Throughout the course we focus on relatively simple, well-studied biological examples, often from microorganisms, because these systems are most suitable for quantitative studies and modeling. |
| Målbeskrivelse: |
At the conclusion of the course students will be able to:
Critically evaluate scientific articles that use quantitative reasoning to investigate biological phenomena
Effectively discuss scientific problems and ideas with peers from disciplines other than their own
Describe the power of mutational analysis.
- Explain the difference between genetic screens and selections and how to apply them to solve biological problems.
- Plan simple genetic experiments.
Describe the basic processes in gene expression.
- Describe the components, speed and error rates of macromolecules involved in gene expression.
- Describe the processes as stochastic processes.
- Describe noise in gene expression.
Describe and explain molecularly different gene regulatory mechanisms.
- Describe the mechanisms with ordinary differential equations.
Describe feedback loops in biological systems, including gene regulatory networks and signal transduction pathways.
- Analyze positive and negative feedbacks using ordinary differential equations.
- Analyze bistability and oscillation seen in biological systems.
Describe the dynamics of signal transduction.
- Describe mechanisms that provide specificity, sensitivity, amplification and adaptation in a signal transduction pathway.
|
| Lærebøger: |
Original articles from scientific journals and supporting materials is provided. There is no textbook for this course. |
| Tilmelding: |
Registration at KUnet from 15 November to 1 December. |
| Faglige forudsætninger: |
The course is open to graduate students and 3rd year bachelor students from biology, biochemistry, biophysics, chemistry, physics, molecular biomedicine and nanotechnology who are interested in quantitative analyses of biological phenomena. There are no specific course prerequisites. |
| Eksamensform: |
A 25-minute oral exam graded according to the 7-step scale and with internal censorship. To be qualified for the exam, a mandatory group presentation must first be approved.
Reevaluation: as the ordinary exam.
|
| Eksamen: |
Mundtlig prøve d. 17-20. juni 2013.
Reeksamen: Mundtlig prøve d. 21. august 2013. |
| Kursus hjemmeside: |
 |
| Undervisnings- sprog: |
Engelsk
|
| Sidst redigeret: |
26/10-2012 |