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| Udgave: |
Forår 2013 NAT |
| Point: |
7,5 |
| Blokstruktur: |
4. blok |
| Skemagruppe: |
A |
| Institutter: |
Biologisk Institut |
| Uddannelsesdel: |
Kandidat niveau |
| Kontaktpersoner: |
Anders Aspberg, Biologisk Institut, tlf. 3532 2048, e-mail: aaspberg@bio.ku.dk |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Forår 2013 NAT |
| Undervisnings- form: |
Lectures, seminars and guest lectures from internationally leading experts in the field. The seminars will include student presentations on primary literature and on methodology based on literature and discussions with teachers. |
| Formål: |
The course aims at giving the students a solid understanding of the normal biology of the extracellular matrix as well as changes in relevant disease conditions.
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| Indhold: |
Most cells are dependent on interaction with the extracellular matrix. This three-dimensional meshwork of (glyco)proteins is present to different degrees in virtually all tissues and provide biomechanical properties to the tissues, but also vital cell biological cues guiding cell proliferation, motility, differentiation and survival. These signals are transmitted to the cells through specific transmembrane matrix receptors, e.g. integrins and syndecans.
Disturbed matrix formation, maintenance and cellular interaction is a key factor in many human disorders. This course will focus on the biology of the extracellular matrix and cell-matrix interactions as well as on matrix-related processes in disease.
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| Målbeskrivelse: |
After completing the course the student will be able to:
• Describe the molecular composition of different types of extracellular matrix in key tissues and organs.
• Explain mechanisms of extracellular matrix assembly and turnover/maintenance
• Understand cellular interactions with the extracellular matrix through specific receptors and the effects of these interactions.
• Explain how dysregulated extracellular matrix assembly and degradation contributes to disease processes, e.g. in musculoskeletal disorders and in cancer metastasis.
• Critically read and summarize original research articles in the field.
• Understand the methodology used in the study of extracellular matrix and related disorders.
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| Lærebøger: |
No specific textbook will be used, although Robbin and Cotran’s ”Pathologic Basis of Disease” may prove useful for reference. Handouts, review articles and original scientific articles will be available on the course website. |
| Tilmelding: |
Registration at KUnet from 15 November to 1 December. |
| Faglige forudsætninger: |
Bachelor level biochemistry and cell biology is a requirement, knowledge in protein chemistry and/or human pathobiology is an advantage. |
| Eksamensform: |
Active participation in the course (at least 80% presence) and satisfactory student presentations of methodology and primary literature (journal club) are required to pass the course.
Examination will be through an essay in the form of a research proposal on a self-chosen topic within the extracellular matrix/cell-matrix adhesion research field. This research proposal essay will be graded pass/non-pass, with internal censorship.
Reexam: The same as the ordinary exam.
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| Eksamen: |
Essay afleveres d. 13. juni 2013.
Reeksamen: Essay afleveres d. 22. august 2013. |
| Kursus hjemmeside: |
 |
| Bemærkninger: |
Maximum enrollment will be 30 students, with 6 of the places reserved for international students. Students at Molecular Biomedicine will be given first priority. Next in line are students with corresponding scientific qualifications, prioritised after their application time. |
| Undervisnings- sprog: |
Engelsk
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| Sidst redigeret: |
30/10-2012 |