|
| Udgave: |
Efterår 2012 NAT |
| ECTS points: |
15 |
| Point: |
15,0 |
| Blokstruktur: |
1. blok, 2. blok |
| Skemagruppe: |
A |
| Fagområde: |
kem |
| Omfang: |
6 hours a week, with 2 hours lectures and 4 hours classes and take-home assignments. |
| Institutter: |
Kemisk Institut |
| Uddannelsesdel: |
Kandidat niveau |
| Kontaktpersoner: |
Jørn B. Christensen, e-mail: jbc@chem.ku.dk, Phone: 35320194 |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT |
| Undervisnings- form: |
Lectures, classes with problem solving and take-home assignments performed in small groups of 2-3 students. |
| Formål: |
The course gives the students a solid background in current organic synthetic and biologically mediated reactions, their uses and their mechanistical basis. The overall goal is to give the student the tools for picking the best practically synthetic solutions for a given problem. |
| Indhold: |
The topics are: Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems. |
| Kompetence- beskrivelse: |
The student should have an overview of organic chemistry and should be able to analyze a synthetic problem and plan a feasible synthesis. The student should also be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims. |
| Målbeskrivelse: |
The students will get 12 take-home assignments during the course, where they are asked to analyse a case story. These assignments can be the planning of a synthesis of a molecule of interest, an analysis of a series of papers or patents dealing with the synthesis of a molecule of interest to medicinal chemistry, and part of the assignment could be to form an independent opinion on for example a specific set of claims from a patent or paper. These assignments have to be approved in order to go the final examination. The evaluation will be based on one of the written reports and on the student’s ability to defend the report with the two parts given equal weight.
Description of the requirements for passing (02), being average (7) and being excellent (12):
02: The student is able to explain the content and the results of the written report.
7: The student is able to explain the content and the results of the written report and shows an understanding of some of the underlying reaction mechanisms.
12: The student is able to explain the content and the results of the written report and shows a complete understanding of the underlying reaction mechanisms.
|
| Lærebøger: |
F. A. Carey, R. J. Sundberg: Advanced Organic Chemistry 5th edition Part B. Relevante videnskabelige artikler |
| Faglige forudsætninger: |
It is highly recommended that the student have a solid background in organic chemistry. The course is compulsory for students following the specializations in “Synthesis” (MSc-programme on Chemistry) and “Medicinal Chemistry” (joint MSc-programme between NAT, FARMA and LIFE). |
| Formelle krav: |
See above |
| Eksamensform: |
There will be 12 take-home assignments during the course, which will have to be approved in order to take the exam.
The exam is an oral examination based on one of the take-home assignments chosen randomly (by lot).
There is an external censor and the grading follows the 7-step scale.
The re-examination is also an oral examination based on one of the take-home assignments chosen randomly (by lot). There is an external censor and the grading follows the 7-step scale.
|
| Eksamen: |
Mundtlig prøve den 25. januar 2013.
Reeksamen: Mundtlig prøve den 19. april 2013. |
| Kursus hjemmeside: |
 |
| Bemærkninger: |
Students who has passed "Reaktioner og syntese", can not attend this course. |
| Pensum: |
Reading for ”Organic Reactions and Synthesis”
Textbook: F. A. Carey & R. J. Sundberg: Advanced Organic Chemistry Part B. (Fifth edition, Springer 2007)
Chap. 1: pp. 1-55.
Chap. 2: pp. 63-200.
Chap. 3: pp. 215-276.
Chap. 4: pp. 289-357.
Chap. 5: pp. 367-461.
Chap. 6: pp. 473- 604.
Chap. 7: pp. 619- 666.
Chap. 8: pp. 675-770.
Chap. 9: pp. 783-852.
Chap. 10: pp. 861-992.
Chap. 11: pp. 1003-1055.
Chap. 12: pp. 1063-1150.
Chap. 13: pp. 1163-1259.
Articles:
P. Knochel, W. Dohle, N. Gommermann, F. F. Kneisel, F. Kopp, T. Korn, I. Sapountzis, V. A. Vu: “Highly Functionalized Organomagnesium Reagents Prepared through Halogen–Metal Exchange”
Angewandte Chemie International Edition 2003, 42, 4302 – 4320.
S. J. Mickel, D. Niederer, R. Daeffler, A. Osmani, E. Kuesters, E. Schmid, K. Schaer,
R. Gamboni: ”Large-Scale Synthesis of the Anti-Cancer Marine Natural Product
(+)-Discodermolide Part 1 – 5” Series of papers in: Organic Process Research & Development 2004
P. J. De Clercq: “Biotin: A Timeless Challenge for Total Synthesis”
Chemical Reviews 1997, 97, 1755-1792.
Ole Kirk and Morten Würtz Christensen: ” Lipases from Candida antarctica: Unique Biocatalysts from a Unique Origin”
Organic Process Research & Development 2002, 6, 446-451.
E. M. Anderson, K. M. Larsson, O. Kirk:”One Biocatalyst - Many Applications:
The Use of Candida Antarctica B-Lipase in Organic Synthesis
Biocatalysis and Biotransfomation, 1998, 16, 181-204.
D. R. Boyd, G. N. Sheldrake:”The dioxygenase-catalysed formation of vicinal cis-diols”
Nat. Prod. Rep., 1998, 15, 309-324.
C. Wiles, P. Watts: “Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist”
Eur. J. Org. Chem. 2008, 1655–1671
S.V. Ley, I. R. Baxendale, G. Brusotti, M. Caldarelli, A. Massi, M. Nesi: “Solid-supported reagents for multi-step organic synthesis: Preparation and application”
Il Farmaco 2002, 57, 321–330.
|
| Undervisnings- sprog: |
Engelsk
|
| Sidst redigeret: |
12/9-2012 |