|
| Udgave: |
Efterår 2012 NAT |
| ECTS points: |
7,5 |
| Point: |
7,5 |
| Point: |
7,5 |
| Blokstruktur: |
2. blok |
| Skemagruppe: |
B |
| Institutter: |
Department of Biology |
| Uddannelsesdel: |
Kandidat niveau |
| Kontaktpersoner: |
Assoc.Prof. Morten Schiøtt, phone 35321233, email: mschiott@bio.ku.dk |
| Andre undervisere: |
Post.doc. Michael Poulsen, Post.doc. Sanne Nygaard, Prof. Anders Krogh, Assoc.Prof. Albin Sandelin, and others. |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT |
| Undervisnings- periode: |
Weeks 47-04 |
| Undervisnings- form: |
The course will entail ca. nine confrontation hours per week for seven weeks, with a combination of lectures, seminars, computer exercises, group discussions, and student presentations of original research papers. |
| Formål: |
The increasing availability of genome data for non-model organisms creates new opportunities for research in ecology, behaviour and evolutionary biology. Such studies were previously restricted to sequencing single genes for phylogenetic reconstructions and to the use of neutral genetic markers for estimating genetic structure of populations. However, the application of second-generation genome sequencing technology means that non-model organisms will increasingly have sequenced genomes, allowing research that addresses the genetics of adaptations at unprecedented levels of detail. This will not only apply to individual study organisms, but also the communities of microbes that have important ecological functions and coevolutionary relationships with multicellular host organisms.
This course will identify and discuss the main applications of genomic data in ecology, behaviour and evolutionary biology, including various ways to identify single genes, genome annotation, pathway reconstruction, population genomics as natural extension of population genetics, community metagenomics, and the use of genomic data for the study of disease and symbiosis. By the end of the course, students will be able to critically evaluate the use and choice of genomic methods for hypothesis testing in biology.
The course is directed at biology students who want to become familiar with the use of genomic data for hypothesis development and testing, and for bioinformatics and biochemistry students with an interest in applying their skills outside classic model systems for which genomes were already sequenced many years ago.
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| Indhold: |
The specific goal of this course is to give students a thorough introduction to the types and applications of the different genomic tools available, including understanding their limitations. We will introduce students to the concepts of genomic, metagenomic, and transcriptomic data acquisition and analyses, primarily during lectures and seminars, but supplemented with some computer exercises. In addition, the course will bring in guest lectures, who are specialists in their field and who use genomic tools to answer questions that are primarily driven by ecology, organisma, or evolutionary biology. In the theoretical seminars the students will present, discuss, and critically evaluate studies from the literature that incorporate genomic data to address questions in ecology, behaviour and evolutionary biology. |
| Målbeskrivelse: |
After successfully completing the course, the students will be able to:
Explain how different types of genomic data are obtained and how they can be analyzed.
Explain how genomic data can increase our understanding of research questions in ecology, behavior and evolutionary biology.
Present, discuss, put into perspective, and critically relate to research papers that use genomic tools.
Critically evaluate alternative genomic tools for addressing specific research questions in these fields.
Independently retrieve and organize course-relevant information from the scientific literature.
Put forth scientific hypothesis and make informed suggestions on how genomic data can be used to hypotheses in biology.
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| Lærebøger: |
A course compendium with recent literature and notes will be made available. |
| Tilmelding: |
Registration 15 May - 1 June via KUnet |
| Faglige forudsætninger: |
The course is open to masters students, and we expect students to have a life science background roughly equivalent to the first two years of Biology or Biochemistry in the Bachelor program of Copenhagen University. |
| Eksamensform: |
Successful completion of the course will require active participation during the course, including presentation and discussion of research papers. The final exam will be a short essay written as a grant proposal, in which students choose a biological system of their own interest (an organism, a symbiosis, a disease), present an evolutionary, behavioral or ecological hypothesis, and address how genomic tools/data can inform research to test the hypothesis. Developed hypotheses will be discussed in small groups of students, but the final grant proposal essay will be written and handed in by each student individually. The essay will function as a starting point for discussion in a final 25-minute oral exam. Grades will be given according to the 7-step scale with the participation of a second independent examiner, with a 50:50 weight of the essay and oral exam. Re-exam: One-week take-home assignment in addition to the essay. |
| Eksamen: |
Aflevering af rapport den 18. januar samt mundtlig prøve den 25. januar 2013.
Reeksamen: Ugeopgave udleveres den 15. april og afleveres den 19. april 2013. |
| Kursus hjemmeside: |
 |
| Bemærkninger: |
Introductory courses in bioinformatics will be an asset, but are not required for successfully completing this course. The course will primarily focus on the principles and concepts of genomic studies. For practical analysis of genomic data other courses are available, e.g. Biological Sequence Analysis and Bioinformatics of high throughput analyses. The course is part of the qualification profiles: Ecology and Evolution and Microbiology. For all courses of the qualification profiles, see Course Portal for Department of Biology. |
| Undervisnings- sprog: |
Engelsk
|
| Sidst redigeret: |
25/4-2012 |