|
| Udgave: |
Efterår 2012 NAT |
| Point: |
7,5 |
| Blokstruktur: |
2. blok |
| Skemagruppe: |
C |
| Fagområde: |
fys |
| Institutter: |
Niels Bohr Institutet |
| Uddannelsesdel: |
Bachelor niveau |
| Kontaktpersoner: |
Kim Sneppen, tlf.3532 5352, sneppen@nbi.dk |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT |
| Undervisnings- periode: |
19. november 2012 til 27. januar 2013 |
| Undervisnings- form: |
Forelæsninger og øvelser |
| Formål: |
To obtain knowledge about networks and information processing
in living systems,
including physics of gene regulation, dynamics on biological networks and dynamics of evolution.
|
| Indhold: |
The course is an introduction to physics of living systems.
It deals with modeling of biological networks, from both a functional and an evolutionary perspective. Topics include basic concepts from molecular biology, physics of gene regulation, models for decision processes inside cells, bi-stability in genetic systems, response dynamics, oscillations, networks, and evolution on both microscopic and macroscopic scale.
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| Målbeskrivelse: |
The purpose of this course is to give the student a basic understanding of life as a physical system. A system that can be modeled in much the same way as other physics systems, with the additional complications that a living system is build of many different parts.
Parts which are put together in a network by the historical process of evolution.
Emphasis is put on modeling, with the aim to teach the students how to construct and analyze dynamic models.
When the course is finished it is expected that the student:
Understand the central dogma, DNA-->RNA-->Proteins and will be able to write equations and algorithms associated to each of the steps. Such models involves stochastic molecular events and knowledge of timescales associated to basic processes inside a living cell.
Understand how the same genome can give rise to widely different genetic activity. Such epigenetics is an important part of life-death decisions in the microbial world, as well as for the development of multicellularity.
Understand principles for gene regulation, meaning that the central dogma is supplemented with numerous back-arrows. An important part of being alive is feedback, and the student should know about feedback associated to both metabolism, and feedback associated to stress.
Understand and model shock responses and conditions for obtaining oscillations inside living cells. This include feedback from stress to the regulation of proteins that counteracts the stress.
Understand networks, and what makes networks relevant for dealing with biological systems.
This include both transcription regulatory networks, and their coupling to the production line networks of metabolism.
Know about evolution in terms of models for how it could have formed the living world. In particular to know about models for evolving molecular networks inside an evolving species, as well as a minimal model for co-evolving animal species.
Knowledge about tools to construct quantitative models for living systems, and thereby increase the students intuition about modeling as a scientific method.
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| Lærebøger: |
Noter kan findes paa hjemmesiden cmol.nbi.dk |
| Tilmelding: |
Foregår på selvbetjeningen d. 15.maj - 1. juni. |
| Faglige forudsætninger: |
Ingen |
| Formelle krav: |
Ingen |
| Eksamensform: |
Mundtlig eksamen der varer 25 minutter uden forberedelsestid. Intern censur og karakter efter 7-trin skalaen.
Reeksamen den samme som ordinær eksamen. |
| Eksamen: |
Mundtlig prøve den 23. januar 2013.
Reeksamen: Mundtlig prøve den 17. april 2013 |
| Kursus hjemmeside: |
 |
| Kursus hjemmeside: |
cmol.nbi.dk/kursus/ |
| Bemærkninger: |
Undervisningen kan foregå på dansk, hvis ingen udenlandske studerende er tilmeldt |
| Undervisnings- sprog: |
Engelsk
|
| Sidst redigeret: |
26/4-2012 |