Biophysics of non-equilibirum processes and evolution


Semesterangivelse: Efterårs kursus Kurset udbydes i blok 2 Kurset udbydes i skemagruppe A Kurset giver 7,5 ETCS point

 


Udgave: Efterår 2012 NAT
Point: 7,5
Blokstruktur: 2. blok
Skemagruppe: A
Fagområde: fys
Institutter: Niels Bohr Institute
Uddannelsesdel: Kandidat niveau
Kontaktpersoner: Thomas Heimburg, tel: 35 32 53 89, office: Kc9, email: theimbu@nbi.dk.
Skema- oplysninger:  Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT
Undervisnings- periode: 19. november 2012 til 27. januar 2013
Undervisnings- form: 6 hours of Lectures, 1 hour of excercises.
Formål: This course goes beyond standard thermodynamics and introduces modern concepts of non-equilibrium process. This will be described the phenomena of life.
Indhold: Biological organisms are open thermodynamic systems with metabolism (food and breathing). Most processes are not in equilibrium. Thermodynamic forces and fluxes drive reaction under consumption of energy and dissipation of entropy. Such processes are irreversible. The understanding of non-equilibrium processes is important to analyze molecular reactions, protein function and metabolism in biology. This course introduces into the thermodynamics of irreversible processes and into the application of these concepts to elementary biological reactions (e.g. channel activities). Under certain conditions stable fluxes (stationary states) develop, or dissipative stuctures can form. Criteria for defining such states are formulated. Ultimately one arrives at the formation of chemical oszillations and biological clocks. In reproducing organisms, such oszillations can lead to reproductive cycles (hypercycles) that compete with other organisms. Fitness is a consequence of reproductive speed, error and death rate. Important key topics of this course are information, self reproduction, self organisation and evolution.
Målbeskrivelse: After this course students should be able to:
- Handle the entropy as a potential
- Derive cycle kinetics and its application to ion pumps
- Work with thermodynamic forces and fluxes
- Work with Onsager's equations, and understand the concept of microscopic reversibility
- Understand the concept of 'information' and its relationship to entropy.
- Describe oscillatory reactions
- Derive the equation for evolution
- Understand the concepts of hypercycles, quasispecies, mutation

12 is given for a presentation where the student displays an independent ability of deriving and working with the concepts described in the course goals 2 is given for an insecure presentation where the student can only reproduce a minimum of what has been described under course goals.
Lærebøger: There will be handouts that are sufficient to understand the course. Recommended is the reading of: "Modern Thermodynamics: From Heat Engines to Dissipative Structures (Paperback) by D. Kondepudi and I. Prigogine".
Tilmelding:
Foregår på selvbetjeningen d. 15.maj - 1. juni
Faglige forudsætninger: Physics bachelor, Chemists and Biologists with previous training in thermodynamics.
Eksamensform: Oral exam for 30 minutes. The student gives a presentation about a subject from the course for 15 minutes without notes and further examination for another 10 minutes. Intern censor. Graded according to the 7 step scale.
Reexam the same as the ordinary.
Eksamen: Mundtlig prøve den 24. januar 2013. Reeksamen: Mundtlig prøve den 18. april 2013.
Kursus hjemmeside:
Kursus hjemmeside: http://membranes.nbi.dk/courses/nonequilibrium.html
Undervisnings- sprog: Kun engelsk
Sidst redigeret: 26/4-2012



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