|
| Udgave: |
Efterår 2012 NAT |
| Point: |
7,5 |
| Blokstruktur: |
2. blok |
| Skemagruppe: |
C |
| Fagområde: |
kem |
| Institutter: |
Kemisk Institut |
| Uddannelsesdel: |
Kandidat niveau |
| Kontaktpersoner: |
Leila Lo Leggio, 3532 0295, HCØ, C310, e-mail: leila@kemi.ku.dk |
| Andre undervisere: |
Anders Kadziola, C316, e-mail: kadziola@kemi.ku.dk
Anders Ø. Madsen, HCØ, C307A, e-mail: madsen@kemi.ku.dk |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT |
| Undervisnings- form: |
Teaching form: the course’s basis part consists of a theoretical part (lectures, tutorials and discussion of original articles) and laboratory or computer-based practical sessions. The practical classes are compulsory. In the last weeks of the course the students will get a chance to go deeper into the subject, through specialized lectures and a visit to the MAX-LAB synchrotron, as well as individual practical projects. |
| Indhold: |
Crystallography is the main technique by which the three-dimensional structures of molecules are determined. One advantage of crystallography is that similar methods can be used to determine the structure of molecules ranging in size from just a few atoms to the size of ribosomal particle (in the MDa range).
The aim of this course is to provide the student with fundamental knowledge about the crystallographic methods to determine the structure of crystalline materials, especially single crystals of bio-macromolecules and small molecules.
Considerable weight is given to the practical part, in which the students will get experience with structure determination and the use of structural databases through laboratory and computer-based practical classes, partially in the form of individual projects.
The students will be trained in critical reading and presentation of technical literature, original articles and own results on structure determination by X-ray crystallography. |
| Målbeskrivelse: |
The students must be able to:
Describe and explain the basic principles of
o Crystallization and diffraction theory
o Crystal symmetry
o Crystallographic structure determination methods
o Structure validation and be able to apply them in a practical context
Determine crystallographic space groups from diffraction data
Solve numerical problems related to diffraction theory
Present, discuss and critically evaluate original articles and literature in the field
Make use of crystal structure databases to evaluate structure quality
Be able to undertake, with some guidance, their own small crystallographic project, including design, performance and interpretation of experiments
Be able to describe own and other’s crystallographic results orally and in writing
The students must have actively participated in the practical classes and written reports describing the results from their experiments. They must carry out a short individual project and write a report describing their results, according to the given guidelines
|
| Lærebøger: |
W. Massa, Crystal structure determination 2nd edition 2004 (chemical crystallography), Springer-Verlag ISBN: 3-540-20644-2; D. Blow, Outline of Crystallography for Biologists, 2002, Oxford University Press, ISBN: 0-19-851051-9. |
| Tilmelding: |
Via selvbetjeningen KUnet i perioden 1.-10. june 2010 |
| Faglige forudsætninger: |
The course is open to students with a BSc-degree in biochemistry, chemistry or nanotechnology. Students with related bachelor degrees (for example biology or molecular biomedicine) may be admitted, but are recommended to contact the teacher before registering in order to discuss their background and qualifications as compared to the level of the course. |
| Eksamensform: |
Five practical reports must be satisfactorily completed before the final exam.
The course will be evaluated by a final exam consisting of an individual short written report on the project (with a weight of 30 per cent) and an oral exam (with a weight of 70 per cent) and graded with marks according to the Danish 7-point scale. Internal censorship
Reexamination has the same form as the ordinary exam. If the student wishes it, a revised written report on the mini-project may be handed in beforehand. |
| Kursus hjemmeside: |
 |
| Bemærkninger: |
Teaching (but not course material) can be in danish if ALL students wish it. Assignments and exams can be in Danish by agreement between individual students and teachers. |
| Undervisnings- sprog: |
Engelsk
|
| Sidst redigeret: |
31/1-2012 |