|
| Udgave: |
Efterår 2012 NAT |
| ECTS points: |
15 |
| Point: |
15,0 |
| Blokstruktur: |
1. blok |
| Institutter: |
Biologisk Institut |
| Uddannelsesdel: |
Kandidat niveau |
| Kontaktpersoner: |
Søren Sørensen, Sektion for Evolution og Mikrobiologi, tlf. 3532 2059, email: sjs@bio.ku.dk |
| Andre undervisere: |
Niels-Ulrik Frigaard, Lars H. Hansen, Michael Kühl, Anders Priemé og gæsteforelæsere. |
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT |
| Undervisnings- form: |
Weeks 1-7 generally include two double lectures (Mondays and Wednesdays 10.15-12.00), two 3-hour discussion classes (Tuesdays and Fridays 9.15-12.00), and a lecture in "New trends in microbiology" (Friday afternoon). Some weeks depart from this general schedule. Practicals take place afternoons (13.00-16.00) of Wednesday to Thursday in week 2, Monday to Thursday in week 3, and Monday and Tuesday in week 4. |
| Formål: |
Objectives:
The objective is to understand the structural and functional attributes of prokaryotes that relate to their ability to live as single-cell organisms or in intimate associations with eukaryotes. This includes an understanding of prokaryotic genetics, prokaryotic physiology, the biology of the major bacterial pathogens, and the potential of bacteria to produce infectious disease in humans.
Goals:
To understand the concept of single-cell, prokaryotic organisms.
To acquire in-depth knowledge about prokaryotic structure, phylogeny, genetics, and physiology.
To understand bacterial pathogenesis and host-pathogen interactions.
To learn about the major human pathogens.
To learn to read, understand, and discuss the primary scientific literature.
To practice effective written presentation of acquired knowledge and ideas.
|
| Indhold: |
Contents:
Week 1: Bacterial interactions
- Bacterial interactions
- Quorum sensing
- Socio-microbiology
Week 2: Microbial biofilm and evolution
- Biofilms
- Evolution of bacteria
- Bioinformatic analysis
Week 3: Bacterial mobile genetic elements
- Mobile genetic elements: Plasmids, transposons, and bacteriophages
- Integrons and transposons
- Horizontal transfer of plasmids in natural environments
Week 4: Bacterial physiology and identification
- Identification and detection of bacteria
- Structure and function of the prokaryotic cell
- Metabolic diversity
Week 5: Symbiotic and pathogenic bacteria
- Bacterial symbionts in animals
- Bacterial inhabitants of humans
Week 6: Bacterial disease mechanisms
- Bacterial disease mechanisms
- Infectious biology in humans of selected bacteria
- From free-living to pathogen: Adaptation to pathogenicity
Week 7: Human bacterial pathogens
- Disease and bacteria in the human intestine
- Gastrointestinal diseases
- Bacterial pathogens with different life styles
|
| Målbeskrivelse: |
By the end of the course students are expected to be able to:
describe the structural and functional attributes of bacteria that relate to their ability to live as single-cell organisms or in intimate associations with eukaryotes
describe the metabolic diversity of bacteria and explain the diversity in an ecological context
describe in detail the different mechanisms behind horizontal gene transfer among bacteria and evaluate their importance to bacterial survival and evolution
describe and discuss plasmid replication, plasmid maintainence and plasmid copy number regulation in bacteria
put into a plasmid perspective the evolution of antibiotic resistance, both in human infections and in various environments
analyze horizontal transfer of plasmids in natural environments
evaluate the importance of biofilm formation to bacterial survival
evaluate quorum sensing in relation to biofilm formation, bacterial physiology, and bacterial pathogenesis
describe and evaluate methods for detection, identification and subtyping of bacteria
describe and analyze the evolution and phylogeny of bacteria
describe the prokaryotic species concept and evaluate different species definitions
describe and evaluate the concept of sociomicrobiology and analyze the importance of bacterial interactions
describe the molecular basis of bacterial mutualistic symbiosis with a selection of animals
describe a selection of bacterial inhabitants of humans and evaluate their physiology in relation to their habitat
evaluate and analyse bacterial adaptations to pathogenicity
describe in detail the mechanisms of bacterial pathogenesis in humans
describe in detail the molecular basis of pathogenesis of selected human pathogenic bacteria and evaluate the potential of these bacteria to produce infectious disease in humnas
use and evaluate molecular methods to investigate bacterial biofilm formation and horizontal gene transfer among bacteria, and analyze subsequent data
analyze, put into perspective, and criticize the primary scientific literature
perform effective written and oral presentation of acquired knowledge and ideas
|
| Lærebøger: |
Madigan, Martinko and Parker: Brock Biology of Microorganisms, and Summers, 1996: The Biology of Plasmids, supplemented with original papers from scientific journals. |
| Tilmelding: |
Registration via KUnet in the period 15 May - 1 June. |
| Faglige forudsætninger: |
Introductory courses in molecular biology and microbiology are recommended. |
| Eksamensform: |
In order to be allowed to the final exam, the student should have participated actively in the course by being present at the exercises (minimum 80% presence at the exercises), and by performing a satisfactory oral presentation based on a scientific paper. Grading by the 7-step scale is based on essay on the practicals (25% of final grade) and final oral exam (75% of final grade) based on curriculum and practicals with external censorship.
Reexam will be held as the ordinary exam.
|
| Eksamen: |
Mundtlig prøve den 6. og den 7. november 2012.
Reeksamen: Mundtlig prøve den 29. janaur 2013. |
| Kursus hjemmeside: |
 |
| Bemærkninger: |
The course is part of the qualification profile Microbiology. For all courses of the qualification profiles, see Course Portal for Department of Biology. |
| Undervisnings- sprog: |
Kun engelsk
|
| Sidst redigeret: |
12/9-2012 |