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Molecular Genetics and Cell Differentiation


Semesterangivelse: Efterårs kursus Kurset udbydes i blok 2 Kurset udbydes i skemagruppe B Kurset giver 7,5 ETCS point

 


Udgave: Efterår 2012 NAT
ECTS points: 7,5
Point: 7,5
Blokstruktur: 2. blok
Skemagruppe: B
Fagområde: bio
Institutter: Department of Biology
Uddannelsesdel: Bachelor niveau
Kontaktpersoner: Geneviève Thon, tlf. 3532 2108, e-mail: gen@bio.ku.dk
Andre undervisere: Other members of the Department of Biology and guest speakers.
Skema- oplysninger:  Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT
Undervisnings- periode: Weeks 47-04
Undervisnings- form:
Approximately 70 contact hours of integrated laboratory exercises, discussions, and lectures.
Formål: The primary goals of this course are
(1) to provide the students with the tools necessary to a critical understanding and evaluation of the primary scientific literature related to the topic of the course;
(2) to consolidate their understanding of the scientific method; and
(3) to stress the importance of model systems in modern Biology. These goals are achieved by an integrated approach combining laboratory exercises and discussions of the primary literature.
Indhold: The course does not use a textbook, but rather a selection of articles from the primary literature. Three articles are prepared each week and discussed in groups of ~16 students supervised by one teacher in three-hour literature sessions. An introduction to each session is provided during the week preceding the discussion in the form of a lecture. The students prepare for the discussion at home ahead of time by reading the articles and attempting to answer a list of questions provided with each article. Research seminars related to the literature topics are given by teachers in the course and guest speakers. Laboratory exercises help understand techniques and concepts encountered in the primary literature. These exercises are designed as experiments rather than demonstrations. The following topics will be covered:
- Variations in gene expression profiles during cellular differentiation
- Histone modifications, chromatin structure, and epigenetic regulation of gene expression
- RNAi: discovery, mechanisms, biological functions
- Roles of micro-RNAs in gene regulation and embryonic development
- Mechanisms of asymmetric cell division
Målbeskrivelse: By the end of the course, the students should be able to:
  • discuss, put into perspective, and criticize articles covered in the course.
  • use their acquired skills and knowledge to discuss, put into perspective, and criticize articles not covered in the course, bearing on topics related to those covered in the course.
  • present the methods used in the articles covered in the course.
  • report and put into perspective results obtained in the laboratory exercises.
  • conceive experiments related to the laboratory exercises or related to experiments presented in articles covered in the course.
    The grade 12 reflects an excellent understanding of the material covered in the course; an excellent ability to critically evaluate articles from the primary literature bearing on the topic of the course that were not covered in the course; and the ability to conceive experimental strategies to address scientific questions related to the topic of the course.
  • Lærebøger: The course does not use a textbook but rather articles from the primary literature.
    Tilmelding: Registration for this course takes place in the period 15 May -1 June through KUnet (self-registration).
    Faglige forudsætninger: Participation is contingent upon having passed General Biochemistry (Almen biokemi) and General Molecular Biology (Almen molekylærbiologi) or similar courses.
    Eksamensform: Take-home exam with external censor, counting for 1/3 final grade, and 4-hour written open-book exam with external censor, counting for 2/3 final grade according to the 7-step scale. The re-exam is an oral exam with external censor.
    Eksamen: Hjemmeopgave afleveres den 18. januar samt skriftlig prøve den 25. januar 2013. Reeksamen: Mundtlig prøve den 19. april 2013.
    Kursus hjemmeside:
    Bemærkninger: Number of participants: Max. 48.
    Undervisnings- sprog: Engelsk
    Sidst redigeret: 25/4-2012



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