|
| Udgave: |
Efterår 2012 NAT |
| Point: |
15,0 |
| Blokstruktur: |
1. blok |
| Fagområde: |
bio |
| Institutter: |
Department of Biology |
| Uddannelsesdel: |
Bachelor niveau |
| Kontaktpersoner: |
Steen Holmberg, gensteen@bio.ku.dk, 3532 2119 |
| Skema- oplysninger: |
Lectures and problem solving:
Weeks 36-41, Monday and Friday from 9 to 12, week 43 Monday from 10 to 12
Introduction to articles:
Weeks 36-38, Tuesday from 13 to 14 or from 14 to 15
Presentatin of articles:
Weeks 39-41 and 43, Tuesday from 13 to 15
Introduction to Laboratory techniques
Week 36, Friday from 12:30 to 15 or from 15 to 17:30
Laboratory exercises:
Week 37, Monday and Wednesday from 13 to 17.
Weeks 38-41, Monday, Wednesday and Thursday from 13 to 17
Week 43, Monday and Wednesday from 13 to 17.
Laboratory exercises and presentation of articles. Summary of experimental results to be presented in poster format at the last session.
Term paper:
Weeks 39-43
Term paper over assigned article.
|
| Skema- oplysninger: |
 Vis skema for kurset
Samlet oversigt over tid og sted for alle kurser inden for Lektionsplan for Det Naturvidenskabelige Fakultet Efterår 2012 NAT |
| Undervisnings- periode: |
See home page for venue of first meeting. |
| Formål: |
Large scale genome projects are presently yielding the complete genome DNA sequences of animals, plants and microorganisms across the globe. Assigning functions to the many new genes of these genomes is a major goal in biology today. This information will produce new tools for plant and animal breeders as well as for the medical and biopharmaceutical industry. The overall goal of the course is for students to understand the genetics that underlie modern biology and medicine including the genetics of human diseases, genetic screens and diagnostics. The participants in the course will acquire a solid background in the principles of genetics and get an introduction to the latest developments while integrating genetics and molecular biology.
Participants will develop quantitative, analytical skills with which to interpret experimental data and solve problems in classical and molecular genetics plus epigenetics and genomics. This knowledge will enable the student to subsequently apply the genetic approach to gain an understanding of almost any biological system. Another goal is to train the students in both oral and written presentation of scientific data. This includes practice in (i) how to critically read original literature during group discussions, (ii) oral presentation of seminars based on articles, (iii) preparation and presentation of their own experimental results in poster format and (iv) written evaluation of original articles in the form of a term paper. |
| Indhold: |
Principles of genetics and genomics at the molecular level will be explored to give students a solid grasp of the genetic approaches used for solving biological and medical problems. The analysis of eukaryotic genomes encompasses mapping of disease causing mutations and DNA markers (RFLP, RAPD, STS etc) by recombination analyses, and the use of genetic model systems to understand basic biological mechanisms. Topics also include gene mutants in forward and reverse genetics; recombination, gene conversion and repair; gene expression, chromatin and regulation; gene functions and networks plus an introduction to epigenetics and gene databases.
These topics will be studied both theoretically and experimentally in the laboratory. The laboratory exercises use Saccharomyces cerevisiae as a model system for eukaryotic molecular genetics. The participants will also obtain experience in searching and analyzing gene sequences in databases using the internet, and in reading and presenting original articles that illuminate the above subjects.
|
| Målbeskrivelse: |
To obtain the top grade, 12
Can solve problems in recombination, mutation, function and regulation of genes and DNA sequences, gene isolation plus gene and genome structure as presented in the recommended textbook and supplemented by the lectures, problem solving, articles and laboratory exercises.
Can integrate the material from the various topics taught in the course.
Complete all laboratory experiments and present the results in the form of a poster, demonstrating an understanding of the aim, results and perspectives of the laboratory exercise.
Present an article and/or act as a questioner/opponent for an article in English using PowerPoint, demonstrating an understanding of the experimental methods and results.
Actively participate in English as a member of the audience in the article training sessions, the poster and article presentations as well as in the problem solving sessions.
Write a term paper in English together with a fellow student starting from an assigned article, demonstrating the ability to obtain and critically interpret the relevant literature. The term paper forms the basis for an individual oral defense of the term paper.
|
| Lærebøger: |
Griffiths, A., Wesslar, S., Carroll, S. and Doebley, J.:
An Introduction to Genetic Analysis, 10th ed. W.H. Freeman, 2010. |
| Tilmelding: |
Enrolment through KUnet during the period 15 May - 1 June. |
| Faglige forudsætninger: |
Open to students studying biochemistry, biology, nanotechnology and molecular biomedicine who have passed all first year courses and half of the second year courses (corresponding to a total of 90 ECTS-points) of their curriculum. Other students must have succesfully completed biochemistry and molecular biology courses at the undergraduate level. |
| Eksamensform: |
A 4 hour written exam at which text book and course manuals are permitted. Grading according to the 7-step scale with participation of external censor for the written exam and internal censor for the half hour term paper defence.
The written exam accounts for 75% and the term paper with oral defence for 25% of the grade.
Reexam will be held as the ordinary exam.
|
| Eksamen: |
Skriftlig prøve den 2. november samt mundtig prøve den 8. og 9. november 2012.
Reeksamen: Mundtlig prøve den 28. januar 2013. |
| Kursus hjemmeside: |
 |
| Kursus hjemmeside: |
Log on KUnet and then choose Absalon in the right menu.
|
| Undervisnings- sprog: |
Engelsk
|
| Sidst redigeret: |
21/1-2013 |